There is more than one way to express it. I believe 'con fluidez' is the most usual way to express this. Native Spanish speakers jump in if I'm wrong.
'Quiero hablar español con fluidez.' 'Hablo inglés con fluidez' etc. I want to speak Spanish fluently. I speak fluent English.
'Quiero hablar bien el español' would be another option. I want to speak Spanish well.
If you're talking about wanting to master all facets of the language, and not just speaking I think
'Quiero dominar el español.' is a good option (I want to master Spanish.)