They kind of express the same meaning, but "You didn't owe me nothing," isn't a correct thing to say. It should be "You didn't owe me anything," or "You owed me nothing," because "You didn't owe me nothing," has a double negative.
Also, "You owe me nothing," is in the present tense, and "You didn't owe me anything," is in the past tense. That can matter sometimes, but in general they do express similar meanings.