What is the difference between in disgust and with disgust ?
Can we say in disgust instead of with disgust ?
What is the main difference between them ?
For example
I looked at him with disgust or in disgust ?

Question

What is the difference between in disgust and with disgust ?
Can we say in disgust instead of with disgust ?
What is the main difference between them ?
For example 
I looked at him with disgust or in disgust ?

Answer

Both prepositions are correct, natural and have the same meaning in this particular expression. However, there is no general rule.