there will be a lot of ways to say that in Korean depending on contexts.
i will write down some examples of it's usage.
1.왜 그래? (다 알면서)
you tell me.
2.왜 그래?(무슨 일이야?)
what happened? or what's going on?
3.(눈이) 왜 그래?
what's wrong with your eyes?
(did you get hurt?)
3.(에이) 왜 그래? (별일도 아닌걸 가지고)
oh, come on! it's not a big deal.
4.(뭐) 왜 그래?
what? what is it? (something's wrong?)
etc..
as i said, it will depend on the situations.