"Goes in tight" sounds like "Gesundheit," which is German for "good health." This is normally said after someone sneezes, and English speakers say it as well. As for why it's funny, you'll need to figure that out for yourself... .
2010년 12월 12일
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If he knows it goes in tight, then she's not a virgin. :P
2010년 12월 13일
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Goes-in-tight sounds like the German "Gesundheit", and is a word every Englishman knows. It's not a very good joke, by the way.