1. Yes, if you've got something 'on lock' it means you've got it totally sorted and under your control. For example if someone asked you how your new job was going, you could say "It's all good, I got it on lock."
2.This can definitely be for if you sort something out, like you said, lock down a new job meaning you have got the job. No one I know says "lock down a time to meet" but that is a perfectly acceptable thing to say and means that you have arranged a definite time to meet that you have both confirmed. A "lockdown" is also when a building or area (commonly a jail) will not let anyone leave or anyone enter.
These are slang words that not everyone uses, but most people will know what you mean even if they don't use them personally.