You usually use the words "he, she, they" when you're referring to an animate thing. There can be exceptions like if you're talking to a child who has a doll, and you refer to the doll as "she/her" because that's how the child is. But, usually, if it's an inanimate object people go with "it/that". Also, native speakers don't really know the gender of people's pets at all. I've noticed (slightly) older generations of English speakers tend to guess the animal's gender, whereas younger ones tend to instinctively say "they". For example, "Oh! They're really cute!". Plural pronouns have a long history of becoming/being used as singular in the English language. (It's why one says "you are" and not "you is" in most standardized forms of English. "You" used to be plural also.)