Using the word "mainstream" as a verb is something that I've only heard of while watching True Blood, which is an American TV series on HBO with vampires, werewolves, shape-shifters, and other mythical creatures.
In the context of this TV show, "to mainstream" means for the vampire to adopt conventional norms and attitudes in order to be accepted in human society. I can therefore imagine Bill Compton (a vampire) saying something like "the only hope for vampire-kind is to mainstream."
Otherwise, in normal, everyday speech, "mainstream" is much more likely to be used as a noun or adjective.
Perhaps you mean "X is TOO mainstream", as in "Starbucks is too mainstream for me."
Or "is to mainstream" could be part of a comparison: "NPR is to radio what PBS is to mainstream TV."
In sum, it's hard to say for sure without seeing the context in which "to mainstream" is used.