The direct translation is "你好吗/你怎么样?" However, due to cultural differences, the Chinese rarely say 你好吗/你怎么样 (how are you?) when they meet someone for the first time. Instead, 你好,很高兴认识你 (Hello, nice to meet you) is already enough.
If you meet an old friend, you may ask "最近怎么样"? (how are you lately/how have you been lately). If you leave out "最近" (lately), in which case you just say "how are you", it will sound weird.