上手 ~ skillful ~ 私は日本語が上手になりたい ~ I wanna become good at Japanese.
よく ~ often ~ 私は日本語をよく勉強しています ~ I often study Japanese.
If you mean 良く ~ well、 良く寝た ~ I slept well
良く Is conjugation of 良い Which you can also conjugate into negative 良くない ~ Not good And so on...