By the way, “go off” is more often seen in set phrases.
We use “go off” with a person “going off against (or on) someone else” often angrily. “The visiting vice president from HQ really went off against the account manager in the meeting yesterday because his account had so many past due invoices.”
Or “go off on a tangent” which is to talk about an unrelated subject. “The same account manager would often go off on tangents in business meetings talking about the favorite sports teams of his clients at length.”