I checked the quote, and I see it's from The Vampire Diaries. So that explains that the "grease" must be internal (though I really liked Jesse's explanation).
The vampire Mikael had just been woken up from a slumber and, like an unused machine, probably felt a little stiff. So Kat suggests that Mikael feed on some blood to renew and refresh his body, using a "rusty machine" analogy: grease will make the parts work more smoothly (ie. Craig's explanation).
So in this context, "grease up" means "give those working parts some 'grease'(blood) to make them work better." The "up" part of the phrasal verb hints at a desired result, eg. sufficiently lubricated.