In your example the phrase "to go off the grid" refers to the idea of hiding from all observation or tracking.
For example, if someone commits a crime, they might attempt to "go off the grid" by avoiding the use of their credit cards, cell phone, and anything else linked to their identity. This would make it difficult for the authorities to find them.
There are a few other common phrases with a similar meaning. If we imagine the same situation of a criminal wanting to hide they might:
"Lay low"/"Lie low"
"Keep a low profile"
"Go into hiding"
All of these phrases imply a similar idea of hiding or avoiding attention, and all are very common in certain genres of films etc.