Hi Sharon, number 1 and 4 are correct.
In Italian the sex of the person speaking doesn't make any difference here.
What matters is if the friend is a male or a female.
All the other elements in the sentence: article (il/la), possessive (mio/mia) and adjective (italiano/italiana) only match the noun AMICO/AMICA.
So you'll say:
La mia amica è italiana
Il mio amico è italiano