Yes, but it is much stronger and used in fewer situations.
e.g. If you are speaking English to someone you can say, "I'm sorry but I don't understand." You can't say 'I can't fathom'.
Also 'fathom' needs an object. 'Understand' dies not.
I don't understand - correct.
But:
I can't fathom his reasons for doing that.
I can't fathom why she's so annoyed.