There are at least different 8 meanings. In your examples, they all mean "to make"/"to manage".
弄脏 = to make it dirty
弄丢 = to make it lost/manage in making it lost
Other similar meanings like "to do", "to handle", "to fool with", "to mess with", "to toy with" depends on the context.
FYI, here are a bit more common connotations of the word.
弄玉/璋 = toying with jade, (usually a name given to a daughter so that a brother may be born for her to play with).
弄权 = abuse of power. Here 弄 means illegitimate use.
弄点钱花 = unable to achieve/get some spare/pocket money
搔首弄姿 = to be dazzle. Here it means to show off.
弄琴 = playing a zither or a passage of music played on the zither. Depends on the context.
弄得人心惶惶 here it means "disturbing"